TNFRSF8 and anaplastic large cell lymphoma: In 2018, brentuximab vedotin was approved for the treatment of patients with previously untreated stage III or IV classical Hodgkin’s lymphoma in combination with chemotherapy and in patients with previously untreated systemic ALCL or CD30+ PTCLs based on ECHELON-1 and ECHELON-2 trials [85,86].