In ECHELON-2 phase III trial, treatment-naïve CD30+ PTCL patients were randomly assigned to receive either BV, cyclophosphamide, doxorubicin and prednisolone (A+CHP) or cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP). The gene discussed is TNFRSF8; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.