Oxidant production by MPO is an advantageous event during phagocytosis and the immune response, but substantial evidence has shown that excess levels of these toxic molecules cause tissue damage, with MPO-mediated damage being implicated in a wide range of inflammatory disease models, including cardiovascular and kidney disease, pulmonary and skin inflammation, neurological disorders, and metabolic syndrome, recently summarized in a review [85]. Here, MPO is linked to nervous system disorder.