IDH2 and glioblastoma: Finally, some LGGs without IDH and H3 K27M mutations have the same genetic alterations as IDH-wt glioblastoma, i.e., gains in chromosome 7, losses in chromosome 10, focal amplifications in EGFR, CDK4 and MDM4, focal deletions involving CDKN2A and RB1, mutations in telomerase reverse transcriptase (TERT) promoter [15,18].