A proportion of IDH-wt diffuse low-grade astrocytomas, located along midline anatomical structures (i.e., thalamus, pons, spinal cord, cerebellum), are characterized by mutation at position K27 in the histone genes H3F3A or HIST1H3B or HIST1H3C [1]. Here, IDH1 is linked to astrocytoma (excluding glioblastoma).