For all the above reasons, we decided to investigate a putative contribution of p53 family member proteins to the potential anti-leukemic effect of iron deprivation on MDS and AML cells, especially since p53 is frequently mutated or deleted in these pathologies [45,46], and it is associated with leukemia onset and relapse [47,48,49,50,51]. This evidence concerns the gene TP53 and myelodysplastic syndrome.