Several genetic syndromes are associated with PPGL: Multiple endocrine neoplasia type 2 (MEN2), Neurofbromatosis type 1 (NF1), Von Hippel–Lindau (VHL) disease, and Hereditary paraganglioma syndrome (PGL 1, PGL2, PGL3 and PGL4) [46,47]. This evidence concerns the gene SDHAF2 and neurofibromatosis type 1.