miR-142-5p is the predominant isoform expressed in thymically derived Tregs and determines peripheral immune tolerance suppressing self-reactive peripheral T effector cell (Teff) responses, thus limiting the development of autoimmunity activity and the upregulation of PDE3B, causing reduced intracellular cAMP and a failure of peripheral tolerance [13]. Here, PDE3B is linked to Autoimmunity.