Detrimental effects of P2X7R were demonstrated in animal models of cerebral ischemia [32] and intracerebral hemorrhage [33,34,35], with proposed involvement of blood brain barrier disruption [33], NLRP3 inflammasome-mediated aggravation of inflammation [34], and the induction of secondary brain injury [35] as underlying mechanisms. Here, NLRP3 is linked to Cerebral ischemia.