Moreover, Cataldo et al. showed that pharmacological prolonged HTR2B activation reduces glucose-stimulated insulin secretion in MIN6 cells (cell line derived from a mouse insulinoma), probably due to an impaired mitochondrial activity and ATP production by mechanisms likely dependent on enhanced peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α/PPARy) levels [63], improving insulin-resistance and, consequently, fatty accumulation in the liver [64]. This evidence concerns the gene INS and pancreatic insulinoma.