KEAP1 (Kelch-like ECH associated protein 1) regulates oxidative stress and apoptosis through interactions with NRF2 in murine vascular cells [60], and endothelial-specific deletion of NRF2 reduces endothelial sprouting in vivo [61] and increases susceptibility to bronchopulmonary dysplasia and other respiratory diseases [62]. The gene discussed is KEAP1; the disease is respiratory system disorder.