Moreover, the extrinsic and the intrinsic apoptotic pathways and their regulators, such as DR4 (Death Receptor 4), TNF receptor type 1-associated death domain protein (TRADD), Fas-associated protein with death domain (FADD) and tumor necrosis factor (TNF) receptor, have been implicated in CLL development [15,16]. Here, TNFRSF10A is linked to B-cell chronic lymphocytic leukemia.