Similar conclusions were reached in the Phase III study KEYNOTE-048 [3]: 882 participants affected by untreated locally incurable R/M HNSCC, stratified by performance status, p16 status and PD-L1 CPS, were randomized in three groups and received, respectively, pembrolizumab alone, pembrolizumab with chemotherapy (platinum and 5-fluorouracil) and cetuximab with chemotherapy. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.