High hMSH2 (Figure 3(Ba)) and hMLH1 expression (Figure 3(Aa)) have been associated with a reduced depth of invasion, and the absence of perineural invasion [57], while MMR deficient tumors (Figure 3(Ab,Bb)) have shown higher rates of bone invasion and high pT stage, and the presence of metachronous neoplasms [67]. The gene discussed is MRC1; the disease is neoplasm.