In vitro cross-linking of MOv18 IgE-bound human monocytes by FRα-expressing IGROV1 ovarian carcinoma cells exhibited the same cytokine signature (TNFα, MCP-1) observed in vivo, with secretion and IGROV1 mRNA expression of MCP-1 inhibited by pretreatment with a TNFα receptor-blocking antibody [32]. This evidence concerns the gene FOLR1 and ovarian carcinoma.