INS and metabolic dysfunction-associated steatotic liver disease: In NHP, juvenile 1-year-old offspring from obese, insulin-resistant dams have a pattern of hepatic gene expression and cytokine and lipogenic responses, i.e., upregulation of SREBP1, SREBP2, FASN, ACC1, LPIN1, and DGAT1 gene expression, consistent with the early stages of NAFLD, despite weaning to a normal diet at 7 months of age [175].