STING1 and neoplasm: More recently, the Ting group used 3′3′-cGAMP-loaded cationic liposomal NPs and showed that they could drive the production of proinflammatory cytokines and nitric oxygen species which promoted macrophage repolarisation from an M2 to an M1 phenotype whilst enhancing STING-dependent anti-tumour immunity in various difficult to treat tumour models [124].