NGF and neoplasm: The current results show that NGF (100 ng/mL) increases c-MYC protein levels in human ovarian surface epithelial HOSE, as well as A2780 and SKOV3 EOC cells, mainly following short incubation times (2 h; p < 0.01, p < 0.01 and p < 0.05, respectively; Figure 1A,C, Supplementary Figure S3) Alternatively, metformin incubation (10 mM, 48 h) strongly decreased c-MYC protein levels in the EOC cell lines (p < 0.01 and p < 0.001: Figure 1B,C), but did not decrease c-MYC protein levels compared with the baseline condition (without stimulation) in the non-tumour cell line HOSE (Figure 1A).