Some studies have shown that presence and expression of NGF and its high affinity receptor TRKA increase during EOC progression, and promote tumour cell proliferation and angiogenesis by activation of the phosphoinositide 3-kinases (PI3K)/ Protein kinase B (AKT) and mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinase (ERK) signalling pathways [4,7,8,9]. The gene discussed is AKT1; the disease is neoplasm.