CCND1 and neoplasm: The inhibition of this signaling leads to the downregulation of most of the gene products involved in cancer cell survival and invasion, especially cyclin D1, COX-2, and c-Myc along with vascular endothelial growth factor (VEGF), MMP-9, and intercellular adhesion molecule-1 (ICAM-1), thus suggesting their involvement in the TNFα-induced tumor cells invasion [198].