Similarly to α-humulene, a suppression in the PI3K/Akt/mTOR/S6K1 signaling by β-caryophyllene oxide, associated to a ROS-mediated activation of mitogen-activated protein kinases (MAPKs) in breast MCF7 and prostate PC3 cancer cells, was reported [201]. The gene discussed is AKT1; the disease is cancer.