The authors hypothesized that an inhibition of 15-LOX can be involved in the pro-apoptotic effects highlighted for β-caryophyllene and β-caryophyllene oxide-enriched fractions of Aegle marmelos extract in lymphoma and neuroblastoma cells, and suggest better characterizing the possible role of these compounds as 15-LOX modulators [149]. Here, ALOX15 is linked to neuroblastoma.