Apart from being found in different inflammatory fluids [74,115,116,117,118], many immune cells express CMKLR1, including dendritic cells, macrophages, monocytes, and natural killer cells [86,119,120,121], which usually infiltrate adipose tissue in obesity [8] or the heart in pathological states [122]. The gene discussed is CMKLR1; the disease is obesity due to melanocortin 4 receptor deficiency.