In isolated working hearts from T2DM mice lacking AdipoR1, an impairment of the myocardial mitochondrial function and coupling is observed [199], an effect that is preserved in healthy mice lacking adiponectin [200], which suggests that adiponectin signalling could have differential roles in the regulation of cardiac biology in pathological and non-pathological conditions. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.