Relaxin blunts the NLRP3 inflammasome (which induces the synthesis of IL-1β and IL-18 in leukocytes and cardiomyocyte pyroptosis and apoptosis as well as increases the risk of MI) via the attenuation of caspase-1 activity through an eNOS-dependent mechanism in conditions of I/R injury [261,262]. The gene discussed is IL1B; the disease is myocardial infarction.