Nesfatin-1 administration to these rats has been shown to exert a beneficial effect by decreasing the expression of pro-inflammatory markers and apoptotic and necrotic cells in the cardiac tissue through AKT and GSK3β signalling, suggesting that nesfatin-1 could have anti-apoptotic and anti-inflammatory properties in the heart after suffering an MI [247]. Here, NUCB2 is linked to myocardial infarction.