In hearts from adiponectin-knockout mice, there is an increased expression of endoplasmic reticulum stress and inflammatory genes such as TNFα and MCP-1, an effect that is reverted by adiponectin treatment of H9C2 cardiomyocytes with induced endoplasmic reticulum stress and in HUVECs in sepsis [223,224]. This evidence concerns the gene TNF and Sepsis.