TNF and Insulin resistance: Thus, due to its proximity to the heart, EAT deregulation can affect myocardial function by increasing cardiac lipid accumulation, insulin resistance, and fibrosis due to a decreased secretion of anti-inflammatory adipokines such as adiponectin and an increased secretion of pro-inflammatory adipokines like leptin, TNFα, IL-1β, IL-6, or resistin [12,19].