According to this observation, in a study carried out in men and women undergoing elective coronary angiography, circulating nesfatin-1 levels were increased in patients with CAD, correlated with the number of >50% stenotic coronary segments and associated with CAD independently of atherosclerotic risk factors, suggesting that high nesfatin-1 levels in patients with CAD may play a role in the development of coronary atherosclerosis [241]. This evidence concerns the gene NUCB2 and coronary artery disorder.