Interestingly, 8 (ELF3, FBXO32, FUT3, GRIN2D, RNASEL, SCNN1A, SREBF1, TINAGL1) of the 220 genes up-regulated by both ATRA and DAPT in HCC-1599 cells are equally induced by the two compounds in MB-157 cells. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.