To evaluate the specificity of the effects exerted by ATRA and DAPT we performed similar experiments in MDA-MB-231, MDA-MB-436 and HCC-38, three TNBC cell lines of the panel which express significant amounts of the intact NOTCH1 protein (Figure 5C) and do not respond to ATRA (Figure 1 and Figure 3C) or DAPT (Figure 3C). This evidence concerns the gene NOTCH1 and hepatocellular carcinoma.