Remarkably, HCC-1599, MB-157 and MDA-MB157 cells are reported to be characterized by internal-deletions of the NOTCH1 gene [4,23,24,25], which causes constitutive expression of N1ICD, the γ-secretase cleavage product and transcriptionally active form of NOTCH1 [26]. Here, NOTCH1 is linked to hepatocellular carcinoma.