In contrast, in another recent study, performed with overexpression of the GLI genes, the authors found that nuclear localization and transcriptional activity of GLI3, but not of GLI1 nor GLI2, in Human melanoma (SKMel29, MeWo), glioblastoma-astrocytoma (U373MG), and cervix carcinoma (HeLa) cells were regulated by rapamycin and protein phosphatase 2A (PP2A). The gene discussed is GLI1; the disease is cervical carcinoma.