GLI1 and esophageal adenocarcinoma: The GLI1 phosphorylation at p.Ser84 was observed upon TNF-α treatment and was suggested to increase GLI1 oncogenic function in the development of esophageal adenocarcinoma, since cells with the GLI1 mutation, p.Ser84Glu had a higher level of colony formation in a soft-agar assay.