GLI1 and rhabdomyosarcoma: The epithelial to mesenchymal transition was diminished by rapamycin in a xenograft model of rhabdomyosarcoma in a manner that inhibited both mTORC1 activity and Hh signaling, demonstrated by inhibition of growth and decreased expression of the Hh key genes: GLI1, GLI2, and PTCH, respectively [81].