FGFR3 and neoplasm: This chimeric gene is generated by the fusion of the coiled-coil domain of transforming acidic coiled-coil 3 (TACC3) with FGFR3. The presence of the coiled-coil domain of TACC3 enhances the dimerization of the fusion protein and activates FGFR3 tyrosine kinase, which in turn stimulates tumor formation [54].