TRPV4 and pulmonary edema: The biological results presented herein confirm that the bicyclic trans-decalin nucleus is a valuable scaffold for the design of new TRPV4 modulators and prompts us to further investigate this field with the aim to obtain new molecules potentially useful for the treatment of pain and pulmonary oedema linked to COVID-19 syndrome, and to search for other scaffolds in the available and continuously increasing libraries of natural labdane derivatives and related compounds.