The B-rapid accelerating fibrosarcoma (BRAF) (dabrafenib, vemurafenib, encorafenib) and mitogen extracellular signal-regulated kinase (MEK) inhibitors (trametinib, cobimetinib, binimetinib) are serine-threonine kinase inhibitors that are active against V600 mutations in melanoma and colorectal carcinomas [39]. The gene discussed is MAP2K7; the disease is melanoma.