AKT1 and cancer: Prompted by the aforementioned findings, and in attempt to develop potent anticancer agents targeting AKT protein, a new series of novel quinazolinone derivatives (2–13) was synthesized and investigated for their cytotoxic activity on cancer cell lines, i.e., HepG2 (human liver cancer), MCF-7 (human breast cancer), and Caco-2 (human colon cancer).