Simple linear regression analyses revealed that the change in the stability of vulnerable coronary plaques significantly correlated with a history of myocardial infarction, baseline stability of vulnerable coronary plaques, and percent stenosis at vulnerable coronary plaque sites (Table 3), whereas the change in the size of vulnerable coronary plaques significantly correlated with change in LDL-cholesterol, LDL-cholesterol < 70 mg/dL, HbA1c, change in HbA1c, renin–angiotensin system inhibitor use, and baseline size of coronary vulnerable plaques (Table 4). This evidence concerns the gene REN and myocardial infarction.