In particular, in patients who developed HCC after drug-induced immunosuppression, the discontinuation of immunosuppressive treatment lead to a spontaneous tumor regression by the reactivation of cytotoxic T-cells, that are able to identify and eliminate the cancer cells [24,25]; there is an increase in programmed death 1 (PD-1) and its ligand (PD-L1) expression as well as tumour infiltrating lymphocytes (TILs) in patients with HCC [26,27], leading to the immunosuppression [28,29]. This evidence concerns the gene CD274 and hepatocellular carcinoma.