More in details, the VEGF would exercise its immunosuppressive role through three main ways: reducing T cell activation by inhibition of the maturation of dendritic cells through nuclear factor kB; creating aberrant tumor vessels and down-regulating the selectins and adhesion molecules (necessary for the adhesion of T cells to the vascular endothelium itself); increasing the number of inhibitory immune cells in the tumor microenvironment. This evidence concerns the gene VEGFA and neoplasm.