No NPTX2 receptors have been identified in CRC; however, its cellular internalization was found mediated by the Wnt/β-catenin receptor, FZD6. Additionally, it has been reported that NPTX2/FZD6 interaction translates in cancer cell proliferation and metastasis formation by triggering the Wnt/β-catenin pathway [29] (Table 1). This evidence concerns the gene FZD6 and cancer.