SPAG6 and leukemia: Among significant hypomethylated targets specific to other-11q23 cases, were genes EN1, a member of EHG family of homeobox genes reported to be deregulated in AML [66]; RASA3, located at one of the aberrant regions in AML [67]; FRMD3, is part of 7 genes that map to commonly deleted region of chromosome 9 [del(9q)] in AML; SPAG6, with a role in PI3K/Akt1 pathway-mediated apoptosis and is also part of six leukemia-associated genes for measuring MRD in AML [68].