Genes of interest with uniquely hypermethylated CpGs within this group included: TREM2, a tumor suppressor involved in Wnt/β catenin, ERK and PIK3/AKT/βcatenin signaling in colorectal and hepatocellular cancer; RREB1 (RAS-responsive element-binding protein 1), a transcription factor involved in RAS signaling pathway; KLF6 (Kruppel like transcription factor) identified as a novel mediator of RUNX1-ETO[RUNX1T1-RUNX1] [t(8;21) target gene]; IGF2BP2, an oncogene with negative correlation with the CEBPA mutation status. This evidence concerns the gene RREB1 and hepatocellular carcinoma.