NPM1 and acute myeloid leukemia: Fourteen of the top 50 uniquely methylated CpGs were hypermethylated in other 11q23 rearranged AML and included genes (Table 2) such as: EPS15, a tyrosine kinase substrate implicated in MLL-ALP5/EPS15 fusion in therapy-related ALL and in AML with trilineage dysplasia [62]; KLF4, Kruppel like factor 4 that is downregulated in NPM1-mutated AML.