As shown in Figure 3E, CCND3, cyclin D3 that forms complex with CDK6 and promotes cell cycle progression was hypomethylated and overexpressed in other 11q23 MLL, t(9;11) and some normal cytogenetics AML and conversely was hypermethylated and under-expressed in t(8;21). Here, CDK6 is linked to acute myeloid leukemia.