Several genes represented in these methylation clusters have shown to be of relevance to AML and included: GSTM1 for which a methylation probe-set cg18938907 (GSTM1) had the 5th strongest evidence for bimodal methylation levels and showed markedly less methylation in subgroups A, C, E than in other subgroups, GSTM1/GSTT1 deletions been implicated in AML and might be a contributor to the observed bimodal distribution [28,29]. The gene discussed is GSTM1; the disease is acute myeloid leukemia.