DNMT3A and acute myeloid leukemia: On top of that, recurrent mutations in several epigenetic genes such as DNMT3A, TET2, IDH1, IDH2, EZH2 [1,11] with significant roles in pathogenesis as well as clinical outcomes have been established in adult AML, however these mutations in epigenetic regulators such as DNMT3A and IDH2 are rare in pediatric AML [12,13,14].