DIRAS1 and acute myeloid leukemia: Additionally we observed multiple genes in RAS pathway to be differentially methylated across the cytogenetic risk groups: RASSF5 and RASGRF1 in inv(16) cases; RASA3 in t(8;21) cases; RASSF2 in t(9;11); RASSF4 in other MLL-(11q23); DIRAS1 in miscellaneous abnormalities and normal cytogenetics AML, highlighting the significance of these pathways and genes impacted in different cytogenetic subgroups.