RUNX1 and acute myeloid leukemia: Among the genes with distinctive methylation in FLT3-ITD vs. FLT3-WT group were CBFA2T3, a fusion partner in CBFA2T3-GLIS2 generated by the inv(16)(p13.3q24.3) discussed above; ITGA2, a RUNX1 target gene involved in platelet aggregation and adhesion with implication in AML predisposition in familial platelet disorders (30545930) and overexpression associated with poor AML prognosis [71].