Additionally, evidence of the CB2R heterodimerizing with the C-X-C Motif Chemokine Receptor 4 (CXCR4) has been observed in metastatic cancer cell lines, resulting in diminished functions of CXCR4 receptor and limited tumor cell migration and progression [151,152]. Here, CXCR4 is linked to metastatic malignant neoplasm.