While CB1R antagonism was shown to induce epileptogenic activity in a cell culture model of status epilepticus and in individuals with a history of epilepsy [357,358], CB1R blockade was shown to be efficacious in decreasing long term consequences of febrile seizures, suggesting potential benefits of preventing seizure-induced changes in endocannabinoid signaling [344]. Here, CNR1 is linked to epilepsy.