Thus, higher levels of CD8+ T cells is correlated with better prognosis in many cancers, including squamous cell carcinomas and urologic malignancies, however, there is growing evidence that sub-set populations of these CD8+ T cells are exhausted and lack their cytolytic activity, as well as the production of effector cytokines leading to impaired the antitumor activity [28,29]. The gene discussed is CD8A; the disease is squamous cell carcinoma.