CD274 and metastatic malignant neoplasm in the lymph nodes: In an immune histochemical study of 37 penile SCC, Udageret al. reported that PD-L1 expression in the primary tumor showed a significant association with regional lymph node metastasis (LNM, p = 0.024), as well as shorter cancer-specific survival (CSS, p = 0.011) [32] Additionally, In a multivariable analysis of 213 penile SCC patients, Ottenhof et al. reported that only diffuse PD-L1 expression in tumor cells was a significant predictor of lymph node metastases with OR of 2.81 (p-value = 0.05).