Additionally, Fas ligand (FasL), TNF-α and PD-L1, as present on CD8+ T cell EVs, and miR-298–5p in CD8+ T cell-derived EVs were naturally orchestrating the populations of mesenchymal stem cells and cancer-associated fibroblasts to prevent cancer progression or, on the contrary, to promote tumour growth [122]. This evidence concerns the gene TNF and cancer.