Another modified peptide, CAP1-6D, an epitope of CEA, has been modified to improve the binding to MHC-I complex and has been shown to trigger a more potent CTL response, and T cells activated have been shown to be cross-reactive with wild-type CAP1 and to recognize CEA+ HLA-A2+ tumor cells [108,109]. This evidence concerns the gene CAP1 and neoplasm.