Besides the overexpressed antigens, TAAs can include: cell lineage differentiation antigens, which are normally not expressed in adult tissue (e.g., tyrosinase, gp100, MART-1, prostate-specific antigen (PSA); prostatic acid phosphatase (PAP)) [22,23,24]; and cancer/germline antigens (also known as cancer/testis), which are normally expressed only in immune privileged germline cells (e.g., MAGE-A1, MAGE-A3, NY-ESO-1, and PRAME) [25,26,27,28,29]. The gene discussed is PRAME; the disease is cancer.