The antigens derived from the aberrantly overexpressed self-antigens in tumor cells compared to normal cells (e.g., RAGE-1, hTERT, HER2, mesothelin, and MUC-1) are defined as tumor-associated antigens (TAAs) and might represent universal antigens among patients with the same malignancy [18,19,20,21]. The gene discussed is MSLN; the disease is neoplasm.