INS and Insulin resistance: Similar to the phenomenon described above for 3-month-old male β-cell-iPLA2β-KO conditional knockout RD-fed mice, at 6 months of age HFD-fed β-cell-iPLA2β-KO mice were also significantly more responsive to insulin than floxed-iPLA2β control mice (Figure 6D), raising the unanticipated possibility that β-cell products might also contribute to the development of HFD-induced insulin resistance.