PLA2G6 and neurodegeneration with brain iron accumulation 2A: Global iPLA2β-null mice produced by homologous recombination exhibit several phenotypic abnormalities, including greatly impaired male fertility [11] and the development of a neurodegenerative condition [12] that is similar to the human genetic disease Infantile Neuroaxonal Dystrophy (INAD), which arises from mutations in the Group VIA PLA2 gene [13,14].