INS and Insulin resistance: This is consistent with the hypothesis that motivated the preparation of the MØ-iPLA2β-KO mice—that HFD feeding would induce a lower deterioration in glucose tolerance and insulin sensitivity in MØ-iPLA2β-KO mice compared to floxed-iPLA2β control mice, possibly because of impaired migration of monocytes into peripheral tissues where their differentiation into cytokine-producing macrophages ordinarily contributes to insulin resistance.