INS and Insulin resistance: A loss of iPLA2β in β-cells would result in impaired insulin secretion and increased sensitivity to lipid-induced injury, but loss of iPLA2β in macrophages might provide relative protection against the HFD-induced deterioration of insulin sensitivity because of an impaired migration of monocytes into extravascular tissues, differentiation into macrophages, and elaboration of cytokines that result in insulin resistance.