Zhang et al.demonstrated downregulatedexpression of miR-135a in ERα+BC cells with acquired TAM resistance; however, the overexpression of miR-135a partially resensitized cells to TAM therapy through the activation of ERK1/2 and AKT pathways and miR-135a targeted genes ESR1, ESRRA, and NCOA1 [89]. This evidence concerns the gene ESR1 and breast cancer.