The PPI analysis identified hub gene signatures, that included BAG3, CDK2, CDKN1A, EZH2, GABARAPL1, HDAC1, MYC, TP53, TRAF1 and VIM. BAG3 was identified to be significantly differentially expressed in Schizophrenia by gene and pathways-based meta-analysis of microarray data [55]. This evidence concerns the gene HDAC1 and schizophrenia.