Moreover, the frequencies of senescent CD8- and CD4-TEMRA and Treg subsets were decreased in patients with E-MDs, E-CVDs and E-MDs/E-CVDs, compared to EH, while the frequencies of the most senescent subsets, CD28−CD57+ in EM (both CD4 and CD8) and EMRA (both CD4 and CD8), accumulated in elderly MD and CVD patients, suggesting that an altered T-cell with senescent features which obtained unique migratory behavior was associated with diseases in the elderly [24]. This evidence concerns the gene CD8A and Menkes disease.