PROC and acute myeloid leukemia: Recently, recombinant soluble thrombomodulin (ART-123), an activator of the intrinsic anticoagulant protein C that is approved for treatment of DIC in Japan, has been shown to be superior compared to heparin in a randomized trial in DIC patients (32% non-APL AML patients) although results were not reported separately for AML patients [85].