MPL and Thrombocytopenia: In refractory cases, the addition of immunosuppressive agents, such as calcineurin inhibitors (i.e., cyclosporin A or tacrolimus), tocilizumab, and rituximab, has been used to control symptoms.[1,18] Thrombopoietin receptor agonists have also been used in patients with persistent thrombocytopenia.[19,20] Although we tried all the above options, except for tocilizumab, due to her allergy to it, our patient followed a fatal clinical course.