One study indicated that the prognosis of early MF is not influenced by phenotype,[23] whereas others indicated that patients with CD8+ MF have a lower rate of disease progression, an indolent disease course, and a good prognosis.[24,25] CD8+ MF shows special clinical features, such as hyperpigmentation and poikiloderma, which, when considering its slow progression, indicate a mild biological behavior.[26] Although CD4/CD8 dual-positive MF is rare, it has been described. This evidence concerns the gene CD4 and mycosis fungoides.