Although high-volume hemofiltration was effective in rapidly reducing HTG, one randomized controlled trial from He et al compared high-volume hemofiltration with the combination of low-molecular-weight heparin and insulin, showing no difference in terms of clinical outcomes and costs.[22] For long-term management of hyperlipidemia/HTG, cholesterol absorption inhibitor and fibrates were utilized. This evidence concerns the gene INS and hyperlipidemia.