The TP63 mutations show rather complete penetrance but highly variable expressivity.[4] Thirdly, In some SHFM cases the conventional karyotyping is sufficient for diagnosis, as it can reveal a large chromosomal aberrations, such as deletions or translocations involving the 7q21-q22 region,[4,32,33] namely SHFM1 locus[34] or deletions of 2q31 (SHFM5).[34,35] Thus, basic GTG banding is still useful and close to molecular testing, as it is a relatively cheap and informative assay in a subset of patients linked to SHFM1 or SHFM5 loci. The gene discussed is DLX5; the disease is split hand-foot malformation.