Li et al. (2013) demonstrated the induction of oxidative stress and endothelial dysfunction in coronary artery endothelial cells by TRAIL, through membrane raft clustering and the activation of the potent pro‐oxidant nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme gp91phox subunit. Here, TNFSF10 is linked to endothelial dysfunction.