Similar effects have been observed in cells where PDI (Lin et al., 2016) or ERp57 expression has been silenced (Li et al., 2019; Ye, Fu, Dou, & Wang, 2018), suggesting that thiol isomerase expression is a pro‐migratory and pro‐survival factor and is targetable for disruption of cancer progression in a number of solid tumour and haematological cancer types. Here, PDIA3 is linked to cancer.