Moreover, in PAX3-FOXO1-driven rhabdomyosarcoma, the fusion protein exploits super-enhancers to set up a CRC machinery in collaboration with the master TFs (MYOG, MYOD and MYCN); this CRC is addicted by rhabdomyosarcoma cells for survival and proliferation (23). The gene discussed is FOXO1; the disease is colorectal carcinoma.