The identified up-regulated proteins Myeloperoxidase, Myeloblastin, Neutrophil Elastase, Cathepsin G, and Azurocidin (MPO, PRTN3, ELANE, CTSG, and AZU1) in naso-oropharyngeal swab samples are discussed to highlight the molecular mechanism changes in the site of infection. The gene discussed is PRTN3; the disease is infection.