Moreover, superimposed hypertension (i.e., uniform increase in pressure) always exacerbated the dilatation, consistent with findings in patients [72], whereas superimposed aging (i.e., additional uniform loss of elastin) had differing effects depending on the degree of the initial insult, which appears to be consistent with findings in Marfan patients whereby stiffness differs from age-matched controls in younger but not older Marfan patients [73]. Here, ELN is linked to hypertensive disorder.