With respect to IL‐1β, IL‐6 and IL‐23 expression in the supernatant from patients with SLE under stimulation with IL‐38 or not, we found that these cytokines were strongly down‐regulated in patients with SLE after being stimulated by IL‐38 (Figure 3B‐D). The gene discussed is IL1F10; the disease is systemic lupus erythematosus.