Intriguingly, we revealed late-stage mitophagy activation (LC3-II activation/accumulation, reduced p62, and mitochondrial protein degradation) in old 3xTgAD mice that was larger as compared to 2xTgAD mice likely pointing-out the contribution of late-stage Aβ accumulation and enhanced pTau to excessive mitochondrial degradation in AD. This evidence concerns the gene SQSTM1 and Alzheimer disease.