IL6 and inflammatory bowel disease: Suicidality and suicidal behavior have a multifactorial origin, and identification of causal markers is critical to advance prevention and treatment efforts.64,65 Increased levels of inflammatory markers, and IL-6 in particular, have been found to be associated with suicidality or suicidal behavior, and patients with chronic inflammatory illnesses, such as inflammatory bowel disease, exhibit increased suicide rates.66,67,68,69 We provide evidence for an association between higher IL-6 signaling and suicidality.