TF and Disseminated intravascular coagulation: Because hyperactivation of the TF system has been observed in sepsis (15) and disseminated intravascular coagulation (DIC), we measured soluble TF in plasma and found much higher levels (mean 278 pg/mL) among fatal LF cases than NLFCs (mean 48.8 pg/mL; p<0.0001) (Figure 2, panel B), but we did not find a correlation between TF and antigen levels among LF patients.