Besides, the EDF genes within subtype 1 were enriched in functions of cell growth, such as "ERBB2 signaling pathway" and "Constitutive Signaling by Aberrant PI3K in Cancer" (Figure 5F), which could affect tumor cell growth, proliferation, and migration by perturbing the PI3K/AKT/mTOR signaling pathway.45, 46, 47. This evidence concerns the gene AKT1 and neoplasm.